Busulphan |
Introduction :
Busulphan is a bifunctional cytotoxic alkylating agent and prototype agent of alkyl sulfonates. Busulphan is a antineoplastic agent, also known as anticancerous drug, unrelated to nitrogen mustards. All alkylating agents have or can form an alkyl group that becomes covalently bound to cellular constituents. Busulphan is used in combination of different types of anticancerous drugs to obtain better therapeutic effects and to reduce the side effects or toxicities.
Busulphan is a bifunctional cytotoxic alkylating agent and prototype agent of alkyl sulfonates. Busulphan is a antineoplastic agent, also known as anticancerous drug, unrelated to nitrogen mustards. All alkylating agents have or can form an alkyl group that becomes covalently bound to cellular constituents. Busulphan is used in combination of different types of anticancerous drugs to obtain better therapeutic effects and to reduce the side effects or toxicities.
PharmacoKinetics:
Volume of distribution is found to be 0.99l/kg and plasma protien binding is 7.4%. and metabolism is reported extensive. Renal Excretion accounts for 10-50% (inactive etabolite), 1% (unchaged) and plasma half life is 2-3 hr.
Indications :
Busulphan is primarily indicated in conditions like Chronic myeloid leukaemia, Granulocytic leukemia, Polycythemia vera, and can also be given in adjunctive therapy as an alternative drug of choice in Myelofibrosis, Thrombocythaemia.
Busulphan is primarily indicated in conditions like Chronic myeloid leukaemia, Granulocytic leukemia, Polycythemia vera, and can also be given in adjunctive therapy as an alternative drug of choice in Myelofibrosis, Thrombocythaemia.
